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Cialis is a Brand (Trade) Name for Tadalafil Which May Be Used to Treat Erectile Dysfunction (Ed) and Benign Prostatic Hyperplasia (Bph). * Cialis (Tadalafil) Works by Blocking the Action of an Enzyme Known as Cgmp-specific Phosphodiesterase Type-5 (Pde-5). This Enzyme Breaks Down Cgmp, a Substance That Induces Smooth Muscles to Relax. Blocking Pde-5 Means Increased Levels of Cgmp Within the Smooth Muscles Which Promotes Muscle Relaxation and Vasodilation (a Widening of Blood Vessels). * High Levels of Pde-5 Are Found in the Penis, Lungs, and Retina. Pde-5 is Also Found Throughout the Body Within the Smooth Muscle Cells of Blood Vessels and Muscles